The aim of the present study is to formulation and evaluation of venlafaxine SR pellets. Venlafaxine is a novel anti-depressant used widely for treatment of generalised anxiety disorder but it is having disadvantage of having less biological half life of about 5 hrs due to extensive hepatic first pass metabolism. So in order to maintain the therapeutic concentration of venlafaxine for a prolonged period of time the SR tablets has been formulated. Hence, in the present the polymers such as Ethyl cellulose, Hydroxypropylmethylcellulose phthalate, EudragitRS100 were used as a coating polymer which helps in providing sustained release. The dissolution studies of the dosage form was performed and analysed by U.V spectrophotometer. Different evaluation parameters such as drug-excipient compatibility; in-vitro drug release was performed and showed acceptable as per pharmacopoeial specification. Different polymers are optimized on the basis of release pattern. The present research work was directed towards the development of a sustained release dosage form of venlafaxine in the form of capsules to be taken once daily. The marketed formulation was evaluated for the in-vitro release studied and formulated product is compared with the marketed product extended release pellets.
Loading....